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崔恒宓
发布日期:2016-03-17浏览次数:字号:[ ]
 

 

崔恒宓,(Hengmi Cui, PhD)

博士生导师,特聘教授

通讯地址:江苏省扬州市大学南路88号

手    机:18796606300

E-mail:hmcui@yzu.edu.cnhcui@nju.edu.cn

 

1.简历

研究兴趣为表观遗传学、表观基因组学和非编码RNA调节等。曾在英国剑桥大学、瑞典Karolinska Institute和Uppsala大学、美国约翰霍普金斯(Johns Hopkins)大学和美国国家卫生研究院 (NIH) 等多个世界著名院校及研究机构学习和工作。于1997年获瑞典Uppsala大学分子与发育遗传学博士学位。其后在美国约翰霍普金斯大学先后作博士后、讲师和助理教授,美国国家卫生研究院 (NIH)资深科学家。2013年被扬州大学作为重点引进人才,聘为特聘教授、扬州大学表观遗传学及表观基因组学研究所所长。江苏省高层次双创人才。在国外从事生物科学前沿研究20年,在SCI杂志发表论文50多篇,包括《Nature》、《Science》、《Nature Medicine》、《Nature Genetics》、《Cancer Cell》等世界一流杂志。文献引用超过6000次。曾获得约翰霍普金斯大学W. Barry Wood优秀博士后奖和优秀Jr. Faculty基础研究奖。现兼任《BMC Medical Genetics》副编 (Associate Editor)、《World Journal of Clinical Oncology》、《World Journal of Experimental Medicine》、《The Scientific World Journal》和《World Journal of Clinical Oncology》编委,南京大学兼职教授,美国人类遗传学会(ASHG)、美国癌症协会(AACR)和美国科学促进会(AAAS)会员。曾担任美国NIH研究项目评委、意大利和奥地利国家科学基金特邀评委。

2.教育经

1978.03-1982.01

南京农业大学(原南京农学院) 畜牧兽医系

农学学士学位

1982.02-1985.01

扬州大学(原江苏农学院)  畜牧兽医系

农学硕士学位

导师:张照教授

1993.09-1997.05

瑞典乌普撒拉(Uppsala)大学  发育和分子遗传系

博士学位

导师:Professor:Rolf  Ohlsson

1997.08-2000.06

美国约翰霍普金斯(Johns Hopkins)大学医学院

博士后

导师:Professor. Andrew  Feinberg

3.研究工作经历 

1985.02--1986.01

 中国科学院上海细胞生物学研究所

  进修

1986.02--1989.03 扬州大学动物科学与技术学院

  助教

1989.04--1992.01 扬州大学动物科学与技术学院 

讲师

1992.01--1992.10 扬州大学动物科学与技术学院

副教授

1992.11--1993.10 英国剑桥大学 Babraham 研究所

访问学者

2000.06--2003.06 美国约翰霍普金斯大学医学院 

讲师(Instructor)

2003.07--2010.06 美国约翰霍普金斯大学医学院 

助理教授

2010.06--至今 南京大学医学院 

教授(兼职)

2011.11--2012.11 美国国家卫生研究院癌症研究所(NCI/NIH) 资深科学家
2012.11--至今 扬州大学动科学院  表观遗传学及表观基因组研究所 

特聘教授

4.国内主持研究课题 

* 环境因素及表观遗传学在肾小球损伤中的机制研究(2012CB517605),国家973项目课题,2012-2016, 课题主持人

* 结直肠癌 IGF2 基因内含子miR-483 的致癌机制研究(81171965),国家自然科学基金, 2012-2015,主持人

* 反义RNA 及抑癌基因表观遗传学沉默分子机制研究 (81372237),国家自然科学基金, 2014-2017,主持人

* 源于鸡内源性白血病病毒的反义长非编码RNA的功能及表观遗传学调控机制 (91540117),重大研究计划,2016-2018, 主持人

5.研究论文

英文文章

1. Cui H, Perspective on application of new biotechnology in pig breeding, Proceedings of a regional workshop on pig selection in Southeast Asia, FAO, 63-67, 1989.

2. Bin Z, and Cui H, Transferrin(Tf) concentration variation in plasma and their relationship to several economic traits in Taihu pigs, Proceedings of a regional workshop on pig selection in Southeast Asia, FAO, 44-48, 1989.

3. Zhihua J, and Cui HH, Genetic potential for improvement of growth and backfat in Taihu pigs, Proceedings of a regional workshop on pig selection in Southeast Asia, FAO, 40-43, 1989.

4. Zhihua J, and Cui H, Selection index for early growth performance in Taihu pigs, Proceedings of a regional workshop on pig selection in Southeast Asia, FAO, 36-39, 1989.

5. Jin R, and Cui H, Reproductive characteristics of Taihu pigs, Pig News & Information (Britain), 3:99-102, 1992.

6. Cui H, et al., Ultrastructure of pig embryos during early development, Proceedings of an International Symposium on Chinese pigs, Harbin, China, 324-327, 1992.

7. Ekstrom TJ, Cui H, Li X, and Ohlsson R. Promoter-specific IGF2 imprinting status and its plasticity during human liver development, Development, 1995;121:309-316. IP:85

8. Ekstrom TJ, Cui H, Nystrom A, Rutanen EM, and Ohlsson R. Monoallelic expression of IGF2 at the human fetal/maternal boundary, Mol Reprod and Develop, 1995;41:177-183.

9. Li X, Adam G, Cui H, Sandstedt B, Ohlsson R, and Ekstrom TJ. Expression, promoter usage and parental imprinting status of Igf2 in human hepatoblastoma: uncoupling of IGF2 H19 imprinting. Oncogene. 1995;11:221-229.

10. Ohlsson R, Ekstrom T, Franklin G, Pfeifer-Ohlsson S, Cui H, Miller S, Fisher R, and Walsh C. Plasticity of Imprinting. In Genomic imprinting: Causes and Consequences. (R. Ohlsson, K. Hall and M. Ritzen, Eds.), Cambridge University Press. 1995;pp. 182-194.

11. Cui H, Xu WX, Powell D, and Newman B. Cloning and sequencing of a pig cdc25 tyrosine phosphatase cDNA, Journal of Animal Science, 1995;73:630.

12. Cui H. and Ohlsson R., An improved protocol for purification of 35S-labelled oligonucleotide DNA probes for in situ hybridization applications. Trends in Genetics, 1996;12:506-507.

13. Li X, Cui H, Sandstedt B, Nordlinder H, Larsson E, and Ekstrom TJ. Expression levels of the Igf2 in the human liver: developmental relationships of the four promoters, Journal of Endocrinology, 1996;149:117-124.

14. Adam GI, Cui H, Miller SJ, Flam F, and Ohlsson R, Allelic specific in situ hybridization analysis: a novel technique which resolve differential allelic usage of H19 within the same cell lineage during human placental development. Development, 1996;122:839-847.

15. Cui H, Hedborg F, He L, Nordenskjold A, Sandstedt B, Pfeifer-Ohlsson S, and Ohlsson R. Inactivation of H19, an imprinted and putative repressor gene, is a preneoplastic event during Wilms' tumorigenesis, Cancer Research, 1997; 57:4469-473.

16. Cui H, Horon IL, Ohlsson R, Hamilton SR, and Feinberg AP.  Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability.  Nature Medicine, 1998; 4:1276-1280.

17. Li YM, Franklin G, Cui H, Svensson K, He XB, Adam G, Ohlsson R, and Pfeifer S. The H19 transcript is associated with polysomes and may regulate IGF2 expression in trans. Journal of Biological Chemistry, 1998;273:28247-28252.

18. Randhawa GS*, Cui H*, Barletta JA, Strichman-Almashanu LZ, Talpaz M, Kantarjian H, Deisseroth AB, Champlin RC, and Feinberg AP.  Loss of imprinting in disease progression in chronic myelogenous leukemia. Blood, 1998;91:3144-3147.(*Co-first author)

19. He L, Cui H, Walsh C, Mattsson R, Lin W, Anneren G, Pfeifer-Ohlsson S, and Ohlsson R Hypervariable allelic expression patterns of the imprinted IGF2 gene in tumor cells. Oncogene, 1998;16:113-119.

20. Ohlsson R, Cui H, He L, Pfeifer S, Malmikumpu H, Jiang S, Feinberg AP, and Hedborg F.  Mosaic allelic IGF2 expression patterns reveal a link between Wilms’ tumorigenesis and epigenetic heterogeneity. Cancer Research, 1999;59:3889-3892.

21. Ohlsson R, Flam F, Fisher R, Miller S, Cui H, Pfeifer S & Adam GI. Random monoallelic expression of the imprinted IGF2 and H19 genes in the absence of discriminative parental marks. Development in Genes Evolution, 1999;209:113-119.

22. Uejima, H, Lee, MP, Cui, H, and Feinberg, AP.  Hot stop PCR: A simple and general assay for linear quantitation of allele ratios. Nature Genetics, 2000;25:375-376.

23. Ohlsson, R., Svensson, K., Cui, H., Malmikumpu, H. and Adam, G. Allele-specific in situ hybridisation (ASISH) Methods in Molecular Biology: Genomic imprinting (A. Ward, editor; Humana Press Inc., Totowa, New Jersey, USA). 2001; pp 153-169.

24. Cui H, Niemitz EL, Ravenel JD, Onyango P, Brandenburg SA, Lobanenkov VV, and Feinberg AP. LOI of IGF2 in Wilms’ tumor commonly involves altered methylation but not mutations of CTCF or its binding site. Cancer Research, 2001; 61:4947-4950.

25. Rhee I, Bachman KE, Park BH, Jair K-W, R-W C, Yen, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, and Vogelstein B. DNMT1 and DNMT3B cooperate to silence genes in human cancer cells, Nature, 2002,;416:552-556.

26. Loukinov DI, Pugacheva E, Vatolin S, Pack SD, Moon H, Chernukhin I, Mannan P, Larsson E, Kanduri C, Vostrov AA, Cui H, Niemitz EL, Rasko JE, Docquier FM, Kistler M, Breen JJ, Zhuang Z, Quitschke WW, Renkawitz R, Klenova EM, Feinberg AP, Ohlsson R, Morse HC 3rd, Lobanenkov VV., BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci USA, 2002;99:6806-6811.

27. Onyango, P, Jiang, S, Uejima, H, Shamblott, MJ, Gearhart, JD, Cui, H, and Feinberg, AP. Imprinting in human embryonic germ cells without germline transmission, Proc Natl Acad Sci U S A, 2002;99:10599-604.

28. Feinberg, A.P., Cui, H. and Ohlsson, R. DNA methylation and genomic imprinting: Insights from cancer into epigenetic mechanisms. Seminars in Cancer Biology, 2002;12:389.

29. Cui H, Onyango P., Brandenburg S, Wu Y., Hsieh C-L and Feinberg AP. Loss of imprinting in human colorectal cancers linked to hypomethylation of H19 and IGF2, Cancer Research, 2002; 62:6442-6446.

30. Cruz-Correa M, Cui H, Powe N, Giardiello FM, Feinberg A., Loss of imprinting of the IGF2 gene is a diffuse colorectal molecular abnormality which may predict colorectal cancer risk, Gastroenterology, 2002; 122 : 297 Suppl.

31. Cruz-Carrea M, Cui H, Giardiello FM, Palmer A, Hylind L, Feinberg A, Loss of imprinting of IGF2 is an epigenetic marker independently associated with colorectal cancer and not related to tobacco or alcohol consumption, Gastroenterology, 2003;124: A550-A550 Suppl.

32. Cui H., Cruz-Correa M., Giardiello F. M., Hutcheon D. F., Kafonek D. R., Brandenburg S., Wu Y., He X., Powe N. R,. & Feinberg A. P., Loss of IGF2 Imprinting: A Potental Marker of Colorectal Cancer Risk. Science, 2003;299:1753-1755.

33. Cruz-Correa M., Cui H., Giardiello F. M., Powe N. R, Hylind L., Robinson A., Hutcheon D. F., Kafonek D. R., Brandenburg S., Wu Y., He X.,. & Feinberg A. P. Loss of imprinting of IGF2 gene, a potential heritable biomarker for colon neoplasia predisposition. Gastroenterology, 2004;126: 964-70.

34. Cruz-Correa M, Zhao RH, Hylind L, Cuffari C, Cui H, Feinberg A, Giardiello F. Genomic imprinting of the insulin growth factor-2 gene is a constant epigenetic abnormality associated with colorectal cancer risk. Gastroenterology, 2004;126:A2-A3 Suppl.

35. Hu Y, Zheng M, Xu Z, Wang X & Cui H. Quantitative real time PCR technique for rapid prenatal diagnosis of down syndrome. Prenatal Diagnosis, 2004;24:704-707.

36. Cui H*, Gius H*, Bradbury CM, Cook J, Smart DK, Zhao S, Young L, Brandenburg SA, Hu Y, Munson PJ, Chuang EY, Mitchell JB, and Feinberg AP, Distinct Effects on Gene Expression of Chemical and Genetic Manipulation of the Cancer Epigenome Revealed by a Multimodality Approach. Cancer Cell, 2004;6:361-371. * Co-first authors.

37. Bjornsson HT, Cui H, Gius D, Fallin MD, Feinberg AP., The new field of epigenomics: implications for cancer and other common disease research, Cold Spring Harb Symp Quant Biol. 2004;69:447-56.

38. Yang R, Murillo FM, Cui H, Blosser R, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB., Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88, J Virol. 2004 78:11152-60. IP:66

39. Hu YL, Chen X, Chen LL, Xu ZF, Wang XR, Cui H. (2006) Comparative genomic hybridization analysis of spontaneous abortion, International Journal of Gynecology & Obstetrics, 2006; 92:52-57.

40. Yang W, Chen Y and Cui H, Application of DNA methylation inhibitors- Decitabine and 5-Azacytidine in cancer research and clinic (review), Journal of Pharmacology, 2006;21: 110-118.

41. Cui H, Loss of imprinting of IGF2 as an epigenetic marker for the risk of human cancer(review), Disease Markers, 2007;23:105-112.

42. Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, Shankavaram UT, Ziegler MS, Stewart C, Kouros-Mehr H, Cui H, Dolginow D, Scudiero DA, Pommier YG, Munroe DJ, Feinberg AP, Weinstein JN, Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells, Mol Cancer Ther., 2007;6:391-403.

43. Dai Y, Wang Z , Li J,Gu X, Zheng M, Zhou J, Ye X, Yao J, Hu Y and Cui H, Imprinting status of IGF2 in cord blood cells of Han Chinese newborns, Int. J. Mol. Sci. 2007; 8: 273-283.

44. Yu W, Gius G, Onyango P, Karp J, Feinberg AP and Cui H, Epigenetic silencing of tumor suppressor gene p15 by its antisense RNA, Nature, 2008;451:202-206.

45. Sun L, Huang L, Nguyen P, Bisht KS, Bar-Sela G, Ho AS, Bradbury CM, Yu W, Cui H, Lee S, Trepel JB, Feinberg AP & Gius D. DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation, Cancer Res. 2008;68:2726-2735.

46. Cui H, Nguyen P*, Bisht K, Sun L, Patel K, Lee R, Kogoh H, Oshimura M, Oshimura M, Feinberg AP, Gius D. CTCFL/BORIS is a methylation independent DNA-binding protein that preferentially binds to the paternal H19 DMR, Cancer Res, 2008;68:5546-51.

47. Bjornsson HT,  Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, Cui H, Yu W, Rongione MA, Ekstr?m TJ, Harris TB, Launer LJ, Eiriksdottir G, Leppert MF, Sapienza C, Gudnason V, Feinberg AP. Intra-individual Change Over Time in DNA Methylation With Familial Clustering, JAMA. 2008;299:2877-2883.

48. Nguyen P, Bar-Sela G, Sun L, Bisht KS, Cui H, Kohn E, Feinberg AP, Gius D. BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression, Mol Cell Biol. 2008;28:6720-6729.

 49. Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, Ji H, Potash JB, Sabunciyan S, Feinberg AP. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet., 2009;41:178-186.

50. Cruz-Correa M, Zhao R, Oviedo M, Bernabe RD, Lacourt M, Cardona A, Lopez-Enriquez R, Wexner S, Cuffari C, Hylind L, Platz E, Cui H, Feinberg AP, Giardiello FM. Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene. Epigenetics. 2009;27;4(2).

51. Zhao R, DeCoteau JF, Geyer CR, Gao M, Cui H, Casson AG. Loss of imprinting of the insulin-like growth factor II (IGF2) gene in esophageal normal and adenocarcinoma tissues. Carcinogenesis. 2009;30(12):2117-22.

52. Cui I & Cui H, Antisense RNA and epigenetic regulation, Epigenomics, 2010; 2(1):139-150.

53. Zhang Y, Diao Z, Su L, Sun H, Li R,  Hu Y, Cui H, miRNA-155 contributes to preeclampsia by downregulating CYR61, Am J Obstet Gynecol., 2010;202(5):466.e1-7.

54. Rodriguez BA, Weng YI, Liu TM, Zuo T, Hsu PY, Lin CH, Cheng AL, Cui H, Yan PS, Huang TH, Estrogen-Mediated Epigenetic Repression of the Imprinted Gene Cyclin Dependent Kinase Inhibitor 1C in Breast Cancer Cells. Carcinogenesis. 2011,  32(6):812-21.

55. Cui H, Antisesne RNAs and modulation of tumor suppressor genes, Long Non-coding RNAs: Regulation of Gene Expression and Drivers of Natural Selection, Horizon Scientific Press,2011,153-166.

56. Zhao X, Tang Z, Zhang H, Atianjoh FE, Zhao JY, Liang L, Wang W, Guan X, Kao SC, Tiwari V, Gao YJ, Hoffman PN, Cui H, Li M, Dong X, Tao YX,A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nat Neurosci. 2013, 16(8):1024-31.

57. Jeong Y, Du R, Zhu X, Yi S, Wang J, Cui H, Cao W, Lowenstein CJ, Histone Deacetylase isoforms regulate innate immune response by deacetylating mitogen-activated protein kinase phosphatase. JLB.  2014, 95(4):651-9

58. Zhang Z, ElSayed AK, Shi Q, Zhang Y, Zuo Q, Li D, Lian C, Tang B, Xiao T, Xu Q, Chang G, Chen G, Zhang L, Wang K, Wang Y, Jin K, Wang Y, Song J, Cui H, Li B, Crucial Genes and Pathways in Chicken Germ Stem Cells Differentiation. J Biol Chem. 2015, 290(21): 13605-21.

59. Yusuf MS, Hassan MA, Elnabtiti AS, Cui H, A single dose of ginger powder, supported with organic acid or probiotic, maximizes the laying, egg quality hatchability and immune performances of laying japanese quails, International Journal of Recent Scientific Research, 2015,6(10), 6707-6711.

60. Tuoyu Geng , Lili Xia, Fuyuan Li, Jing Xia, Yihui Zhang, Qianqian Wang, Biao Yang , Sean Montgomery, Hengmi Cui , Daoqing Gong, The role of endoplasmic reticulum stress and insulin resistance in the occurrence of goose fatty liver, Biochemical and Biophysical Research Communications, 2015, 465, 83-87.

61. Bo Gao, Dan Shen, Songlei Xue, Cai Chen, Hengmi Cui* and Chengyi Song*,The contribution of transposable elements to size variations between four teleost genomes,. Mobile DNA,  2016 Feb 9;7:4. doi: 10.1186/s13100-016-0059-7. * co-responding authors.

62. Xuming Hu, Wenqi Zhu, Shihao Chen, Yangyang Liu, Zhen Sun, Tuoyu Geng, Xiaoyan Wang, Bo Gao, Chengyi Song, Aijian Qin and Hengmi Cui, Expression of the env gene from the avian endogenous retrovirus ALVE and regulation by miR-155, Archives of Virology, 2016, Accepted

63. Jichang Zhao, Jinghui Yao, Fuyuan Li, Zhe Yang, Zhen Sun, Liang Qu, Kehua Wang, Yijun Su, Tuoyu Geng, Hengmi Cui, Identification of candidate genes for chicken early- and late-feathering, 2016, Poultry Science,  2016 Accepted

64. Xuming Hu, Wenqi Zhu, Shihao Chen, Yangyang Liu, Zhen Sun, Tuoyu Geng, Xiaoyan Wang, Bo Gao, Chengyi Song, Aijian Qin and Hengmi Cui, Expression patterns of endogenous avian retroviruses, ALVE1, and its response to infection of exogenous avian tumor viruses, BMC Medical Genetics, 2016, Under reviewing

65. Hengmi Cui, Yuan Liu, Jingrui Jiang, Yangyang Liu, Zhe Yang, Shaogen Wu,  Wangsen Cao, Isabelle H. Cui,Chenggong Yu, IGF2-derived miR-483 mediated oncofunction through targeting DLC1 and was a potential noninvasive biomarker of colorectal cancer, Oncotarget, 2016, Revised

中文文章

1. 崔恒宓,生物新技术与猪品种改良,《当代畜牧》 1990年 04期:1-2

2. 李碧春,经荣斌,龚允陈,林大光,崔恒宓,毛九德,李松,二花脸猪早期胚胎发育的初步研究,《养猪》 1993年 01期:29-33

3. 崔恒宓,经荣斌,金韶华,毛九德,储新生,唐士余,龙广凤,复合免疫增强剂对仔猪增重及血像和某些免疫学指标的影响,《养猪》 1993年 01期:5-6

4. 经荣斌,崔恒宓,章世元,毛九德,刘铁铮,葛云山,徐晓波,储新生,唐士余,龙广风,商品肉猪快速生长饲养技术试验报告,《养猪》 1992年 04期:18-19

5. 崔恒宓,葛翔,詹彩娇,丁广新,新配合料与50%“311”料饲喂乳猪对比试验,《畜牧与兽医》 1989年 06期:247

6. 崔恒宓,正确对待猪的微量元素添加剂,《养猪》 1989年 02期:10

7. 崔恒宓,猪胚胎死亡原因,《上海畜牧兽医通讯》 1990年 05期:40-41

8. 崔恒宓,猪胚胎移植技术研究进展,《国外畜牧科技》 1987年 05期:18-20

9. 经荣斌,崔恒宓,太湖猪若干经济性状的研究及利用,《养猪》 1991年 03期:26-30

10. 崔恒宓,姜曲海母猪性发育过程中血浆雌二醇和孕酮含量变化的研究,《江苏农学院学报》 1986,7(8):7-11

11. 崔恒宓,张牧,章世元,周鹂,马德雨,戴金星,哺乳仔猪补料中添加土霉素试验,《上海畜牧兽医通讯》 1989,1:18-19

12. 崔恒宓,经荣斌,张牧,张照,香猪生殖器官的发育及血浆雌二醇和睾酮含量变,《中国畜牧杂志》 1989年 第25卷 第5期:13-16

13. 崔恒宓,母猪胚胎死亡原因,《国外畜牧科技》 1990年4月 第17卷 第2期:18-20

14. 崔恒宓,经荣斌,许泉法,吴光华,付堂兵,添加柠檬酸对哺乳仔猪影响的初步研究,《畜牧与兽医》1991年 第5期(23卷):201-202

15. 张彬,张照,崔恒宓,猪血浆转铁蛋白含量火箭免疫电泳法研究,《湖南农学院学报》 1992年12月 第18卷 第4期:986-990

16. 林大光,经荣斌,孙长美,成勇,崔恒宓,李碧春,龚允成,杜淼,邹贤刚, 沈三兵,陆德裕,猪的胚胎嵌合试验中若干技术环节的研究,《江苏农学院学报》 1992,13(1):19-24

17. 张牧,崔恒宓,经荣斌,香猪生长发育规律初探,《上海实验动物科学》 1992,12(1):31-33

18. 崔恒宓,张照,严忠慎,周建梁,姚连生,姜曲海母猪发情周期性腺激素及其子宫受体含量的变化规律,《畜牧兽医学报》 1992,23(1):8-12

19. 汪世新,陈天,经荣斌,崔恒宓,毛九德,新型铜饲料添加剂的合成,《江苏农学院学报》 1994年 第4卷:66

20. 徐万祥,石其贤,崔恒宓,大量分离纯净猪卵透明带的一种简便方法,《生殖与避孕》 1994年 14卷 4期:316-317

21. 崔恒宓,金韶华,毛九德,经荣斌,何良梅,猪脾转移因子的部分生化和免疫性及其应用,《畜牧兽医学报》  1994 25(4):317-322

22. 经荣斌,崔恒宓,汪世新,毛九德,张牧,储新生,尤广凤,氨基酸鳌合铜饲喂生长肥育猪的试验,《江苏农学院学报》 1995 16(3):47-50

23. 张牧,经荣斌,崔恒宓,香猪的生长发育、繁殖特性及其实验动物化研究,《养猪》 1996(2):30-32

24. 吴一迁,崔恒宓 基因组印记与癌症,《肿瘤》 2002年3月25日 第22卷 第2期:154-156

25. 吴一迁,崔恒宓,万曙光,金晏,罗海涛,许丽,于永梅,钱耕荪,乙肝病毒对DNA修复基因和肝癌发生的作用,《肿瘤》 2002年9月25日 第22卷 第5期:379-381

26. 郑明明,胡娅莉,许争峰,王志群,史婷琦,叶晓东,崔恒宓,实时荧光定量聚合酶链反应技术在产前诊断唐氏综合征中的应用,《中华妇产科杂志》 2004年10月 第39卷 第10期:34-37 

27. 胡娅莉,徐运,崔恒宓,王心如,胚胎干细胞的研究进展,《医学研究生学报》 2005,18(1):77-80

28. 杨薇 ,陈银海 ,崔恒宓,地西他滨和5_阿扎胞苷在癌症研究及临床上的应用,《中国药学杂志》 2006年11月 第41卷 第21期:1601-1605

29. 刘媛,蒋菁蕊,吴少亘,曹望森,于成功,崔恒宓,miR-483与结直肠癌关系的研究,《胃肠病学》,2014, Vol.19 (3)151-155

30. 蒋菁蕊,刘媛,吴少亘,曹望森,于成功,崔恒宓,miR-483-3p抑制 DLC1表达促进结直肠癌发生,《胃肠病学》,2014,Vol.19 (7)394-403。

31. 刘洋洋,崔恒宓,DNA甲基化分析中DNA样本重亚硫酸盐处理转化效率的评估方法,《遗传》2015,37(9):939-944。

32. 朱文奇,胡序明,陈世豪,崔恒宓,禽内源性反转录病毒ALVE表观遗传学分析方法建立及利用,《中国动物传染病学报》2015,23(5): 15-20.

33. 胡序明,朱文奇,陈世豪,崔恒宓,禽内源性反转录病毒ALVE1 env转录物表达及其调控分析,《中国动物传染病学报》2015,23(5):27-31.

34. 沈丹,谢雨琇,李庆平,薛松磊,史云强,王赛赛,陈才,钱跃,高波,崔恒宓,宋成义,多转座子载体的构建及转座特性比较研究, 《中国农业科学》2015,48(11):2270-2278.

35. 朱文奇,胡序明,陈世豪,刘洋洋,孙振,耿拓宇,宋成义,高波,崔恒宓, miR-155体外特异性靶向鸡内源性反转录病毒ALVE1 env转录物, 《畜牧与兽医》,2015,23(5)15-20.

36. 田净净 刘洋洋 杨哲 刘菲菲 杨祎擎 韩笑 耿拓宇 高波 宋成义 崔恒宓,利用CRISPR/Cas9系统高效敲除斑马鱼lncRNA基因启动子区,《中国农业科学》,2016,49(1):

7.科学杂志编委 

2011-present  Open Medicine Journal (Associate Editor)

2009-present  BMC Medical Genetics (Associate editor),

2010-present   World Journal of Clinical Oncology (Editorial Board Member)

2011-present World Journal of Experimental Medicine (Editorial Board Member)

2011-present TheScientificWorldJournal (TSWJ) (Editorial Board Member)

8.招收博士后

招收博士后(2-3名)

   研究方向为人类疾病的表观遗传学机制研究、内源性反转病毒的表观遗传学调控及其功能研究、非编码RNA调节机制和功能研究、表观基因组学在动物育种改良中的应用,包括研究基因组DNA甲基化与动物经济性状相关性及研究环境因素改变生物性状的表观遗传学调节机制等研究。欢迎有志者踊跃申请加入。?

应聘条件:?

1、在表观遗传学、或分子生物学和遗传学、或病毒学和免疫学,或生物信息学等相关专业即将或新近(1-2年内)获得博士学位者,在SCI期刊发表过第一作者研究论文;?

2、有较强的独立思考、实验设计和动手能力;?

3、有较强的专业英文阅读和写作能力;?

4、富有科研热情和团队协作精神;?

5、为人诚信,身体健康,工作认真。?

待遇:?

     将参照扬州大学人才待遇执行。有机会出国进行国际合作研究,优秀者可作为师资博士后录用,并享受副教授待遇,博士后完成后留校任教。?

     请海内外有兴趣的应聘者将简历和求职信,用Email发送至:hmcui@yzu.edu.cn?(邮件标题请注明“应聘博后”)。符合要求者,将于近期安排面试或电话面谈。应聘者需提交学历证明及两位教授的推荐信。应聘材料将予以保密,恕不退还。

 

9.招收博硕士研究生 

招收博士研究生2名(动科学院和医学院)

研究方向:

1.肿瘤表观遗传学及功能基因组学

2.表观遗传学和遗传育种

3.非编码RNA鉴定及其功能

4.内源性病毒调控、功能及作用研究

5.RNA甲基化及其功能

6.肿瘤早期诊断新方法研究

招收硕士研究生3名

研究方向:

1.肿瘤表观遗传学

2.内源性病毒的表观遗传学功能研究

3.表观遗传学和遗传育种

4.RNA甲基化及其功能

5.非编码RNA鉴定及其功能

?




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