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曾申明
发布日期:2016-03-18浏览次数:字号:[ ]

 

  曾申明(1968-),男,安徽舒城人,扬州大学特聘教授,中国党员,主要

  从事家畜繁殖理论与技术研究。

  通讯地址:扬州市文汇东路48号动物科学与技术学院

  E-mailzengshenming@gmail.com

  1.学习简历

1987.09-1991.07

安徽科技学院

学士

1991.08-1996.07

中国农业大学

博士

  2.工作简历

1996.08-1998.12

中国农业大学

讲师

1998-2000

新西兰AgResearch分子胚胎实验室

合作研究

1999.01-2003.09

中国农业大学

副教授,硕导

2011.10-2012.10

美国西北大学医学院生殖医学中心

博士后

2003.10-至今

中国农业大学

教授,博导

2015.05-至今

扬州大学

特聘教授,博导

  3.学术任职

中国畜牧兽医学会动物繁殖学分会、马学分会常务理事、中国奶业协会理事、中国畜牧兽医学会高级会员;American Society for Biochemistry and Molecular Biology (ASBMB)会员。

  4.研究方向

1)从miRNA角度探索了猪生殖细胞的热应激抵御与损害机制。

2)发现BimEL蛋白在调控哺乳动物卵泡闭锁中发挥关键作用。

3)发现反刍动物妊娠信号IFN-τ自分泌调控牛、羊早期胚胎发育的分子机制。据此理论设计的新型胚胎培养液和移植液能明显提高牛胚胎体外发育率和移植后受胎率。

4)提出哺乳动物卵子老化新机制。

5)积极开展牛、绵羊、山羊、马和驴的胚胎移植和繁殖控制技术的推广工作。

  5.科研成果

近几年发表的论文:

  1.Gao Fang-Fang, Wu Zhong-Yi and Zeng Shen-Ming. Bovine interferon-tau expression in Escherichia coli and identification of its biological activities. Chinese Journal of Agricultural Biotechnology 5(3); 189–195; 2008.

  2.Shuaishuai WU, Heng CHEN, Yingzheng WANG, Hui GAO, Shenming ZENG. Effect of calcium on porcine ICSI embryos expressing EGFP is related to activation of ooplasmic DNase I. Front. Agr. Sci. Eng. 2015, 2(1): 84–89.

  3.Y. Yuan, Z.D. Hao, J. Liu, Y. Wu, L. Yang, G.S. Liu, J.H. Tian, S.E. Zhu, S.M. Zeng. Heat shock at the germinal vesicle breakdown stage induces apoptosis in surrounding cumulus cells and reduces maturation rates of porcine oocytes in vitro. Theriogenology.2008.70:168–178.

  4.Cui Mao-sheng, Yi-peng Fan, Jin-hao Liu, Yi Wu, Ze-dong Hao, Peng-cheng Wan, Lin Yang, Fang-fang Gao, Shen Liu, Hen Chen, Shen-ming Zeng. Porcine cumulus cell influences ooplasmic mitochondria–lipid distributions, GSH–ATP contents and calcium release pattern after electro-activation. Theriogenology 71 (2009) 412–421.

  5.Yao Ning, Peng-cheng Wan, Ze-dong Hao, Fang-fang Gao, Ling Yang, Mao-sheng Cui, Yi Wu, Jing-hao Liu, Shen Liu, Heng Chen, Guo-shi Liu, Jian-hui Tian, Shi-en Zhu and Shen-ming Zeng. Expression of interferon-tau mRNA in bovine embryos derived from different procedures. Reprod. Dom. Anim. 44, 132–139 (2009).

  6.Yi Wu, Cheng-Jun LiuPeng-Cheng Wan, Ze-Dong Hao, Shen-Ming Zeng. Factors affecting the efficiency of producing porcine embryos expressing enhanced green fluorescence protein by ICSI-mediated gene transfer method. Anim. Reprod. Sci. 113156–166 (2009).

  7.Ze-Dong Hao, Liu S, Wu Y, Wan PC, Cui MS, Chen H,Shen-Ming Zeng. The changes in mitochondria, lipid droplets, ATP and glutathione contents in porcine oocyte during ageing in vitro associate with decreasing Ca2+ release and poor developmental competence after electro-activation. Reproduction Fertility and Development 21: 323-332, 2009.  

  8.Peng-cheng Wan, Ze-dong Hao, Ping Zhou, Yi Wu, Ling Yang, Mao-sheng Cui, Shou-ren Liu, Shen-ming Zeng. Effects of SOF and CR1 media on developmental competence and cell apoptosis of ovine in vitro fertilization embryos.  Anim. Reprod. Sci. 114:279–288,2009.

  9.Yang L., X. L. Wang, P. C. Wan, L. Y. Zhang, Y. Wu, D. W. Tang, and S. M. Zeng. Up-regulation of expression of interferon-stimulated gene 15 in the bovine corpus luteum during early pregnancy. J. Dairy Sci. 93:1000-1011; 2010.

  10.Mao-Sheng Cui, Xian-Long Wang, Da-Wei Tang, Jing Zhang, Yan Liu, Shen-Ming Zeng. Acetylation of H4K12 in porcine oocytes during in vitro aging: potential role of ooplasmic reactive oxygen species. Theriogenology.  2011.75: 638–646.

  11.Tang D. W. and S. M. Zeng.  Relationships of Ca2+ oscillations and ER cluster distribution to porcine oocyte fragmentation. Asian journal of animal and veterinary advances.  2011.6(4): 322-332.

  12.Peng-cheng Wan, Zhong-jian Bao, Yi Wu, Ling Yang, Ze-dong Hao, Yong-lin Yang, Guo-qing Shi, Yan Liu and Shen-ming Zeng. αv β3 integrin may participate in conceptus attachment by regulating morphologic changes of the endometrium during periimplantation in ovine. Reprod. Dom. Anim. 2011.46(5): 757-942.

  13.Ahmed S. Abdoon, Omaima M. Kandil, Shen M. Zeng and Cui MS. Mitochondrial distribution, ATP-GSH contents, calcium [Ca2+] oscillation during in vitro maturation of dromedary camel oocytes. Theriogenology 76 (2011) 1207–1214.

  14.Wu Yi, Cheng-Jun LiuPeng-Cheng Wan, Ze-Dong Hao, Shen-Ming Zeng. BIMEL-mediated apoptosis in cumulus cells contributes to degenerative changes in aged porcine oocytes via a paracrine action. Theriogenology 2011,76:1487-1495.

  15.Cui Mao-sheng, LIU Zhen-xing, Xian-long Wang, Jing Zhang, Yi Wu, Guo-cai Han, Shen-ming Zeng. Relationship between Differential Expression of Bax and Bcl-2 Genes and Developmental Differences of Porcine Parthenotes Cultured in PZM-3 and NCSU-23. Agricultural Sciences in China, 2011, 10(11): 1772-1780.

  16.Xian-Long Wang, Yi Wu, Lu-Bin Tan, Zhen Tian, Jing-Hao Liu, De-Sheng Zhu, and Shen-Ming Zeng. Follicle-stimulating hormone regulates Pro-apoptotic protein Bcl-2-interacting mediator of cell death-extra long (BimEL) induced porcine granulosa cell apoptosis. The Journal of Biological Chemistry, 2012, 287(13):10166–10177.

  17.Ling Yang, Le-Ying Zhang, Cheng-Ming Wang, Bin Wang, Xue-Min Wang and Shen-Ming Zeng. Differential expression pattern of ISG15 in different tissue explants and cells induced by various interferons. Microbiology and Immunology, 2012; 56: 163–170.

  18.Xian-Long Wang, Kun Wang, Guo-Cai Han, Shen-Ming Zeng. A potential autocrine role for interferon tau in ovine trophectoderm. Reprod. Dom. Anim. 2013; 48: 819–825.

  19.Xian-Long Wang, Kun Wang, Shen-Ming Zeng. Oocyte-secreted growth differentiation factor 9 inhibits BCL-2-interacting mediator of cell death-extra long expression in porcine cumulus cell. Biology of Reproduction.2013,89: 56-64.

  20.Da-Wei Tang,Yuan Fang,Zhen-Xing Liu, Yi Wu, Xian-Long Wang, Shuan Zhao,Guo- Cai Han and Shen-Ming Zeng. The Disturbances of Endoplasmic Reticulum Calcium Homeostasis Caused by Increased Intracellular Reactive Oxygen Species Contributes to Fragmentation in Aged Porcine Oocytes. Biology of Reproduction. 2013, 89:124-131.

  21.Liu Z, Zhao S, Wu S, Zhang J, Nie Z, Zeng S. A novel role of transient receptor potential mucolipin1 (TRPML1) in protecting against imidazole-induced cytotoxicity. Biochem Cell Biol. 2014, 92(4): 279-86.

  22.Zhong-Jian Bao, Shuan Zhao, Ihtesham Ul Haq and Shen-Ming Zeng. Recombinant bovine interferon-τ enhances in vitro development of bovine embryos by upregulating expression of connexin 43 and E-cadherin. J. Dairy Sci. 2014; 97(11):6917-25.

  23.Yu Guangmin, Ihtesham ul Haq, Sher Hayat Khan and Zeng Mingsheng. Actin Filaments are Necessary for FSH-Induced CYP19A1 Transcription in Bovine Granulosa Cells in vitro. Pakistan Veterinary Journal, 2015, 35(1): 53-57.

  24.Zhenxing Liu, Yingzheng Wang, Shuan Zhao, Jingyou Zhang, Yi Wu and Shenming Zeng. Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via increasing FoxO3a-Bim expression. International Journal Oncology. 2015, 46(2): 721-31.

  25.Zhao S, Liu Z-X, Bao Z-J, Wu Y, Wang K, Yu G-M, Wang C-M, Zeng S-M. Age-associated potency decline in bovine oocytes is delayed by blocking extracellular Ca2+ influx. Theriogenology. 2015, 83(9): 1493–1501.

  26.Shuan Zhao, Zhen-Xing Liu, Hui Gao, Yi Wu, Yuan Fang, Shuai-Shuai Wu, Ming-Jie Li Jia-Hua Bai, Yan Liu, Alexander Evans, Shen-Ming Zeng. A three-dimensional culture system using alginate hydrogel prolongs hatched cattle embryo development in vitro. Theriogenology 2015, 84(2): 184-192.

  27.Y Fang, W Shang, DL Wei, SM Zeng. Cited2 protein level in cumulus cells is a biomarker for human embryo quality and pregnancy outcome in one in vitro fertilization cycle. Fertility and Sterility. Available online 23 January 2016.

  28.Hui Gao, Lu Lin, Ihtesham Ul Haq, Shen-ming Zeng. Inhibition of NF-κB promotes autophagy via JNK signaling pathway in porcine granulosa cells. Biochemical and Biophysical Research Communications. 2016, 473: 311–316.

  29.Shuan Zhao, Yi Wu, Hui Gao, Alexander Evans and Shen-Ming Zeng. Roles of interferon-stimulated gene 15 protein in bovine embryo development. Reproduction, Fertility and Development. http://dx.doi.org/10.1071/RD15209,2016.

  30.Jieyun Li, Hui Gao, Zhen Tian, Yi Wu, Yingzheng Wang, Yuan Fang, Lu Lin, Ying Han, Shuaishuai Wu, IhteshamUl Haq and Shenming Zeng. Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary. Journal of Animal Science and Biotechnology .2016, 7:57-67.

  31.Guang-Min Yu, Jia-Hua Bai, Yan Liu, Teruo Maeda, Shen-Ming ZengA weekly postpartum PGF2a protocol enhances uterine health in dairy cows. Reproductive Biology. 2016,16(4): 295–299.

  32.Ihtesham Ul Haq, Ying Han, Tariq Ali, Yingzheng Wang, Hui Gao, Lu Lin, Yi Wu, Shuaishuai Wu, Shenming Zeng. Expression of interferon-stimulated gene ISG15 and ubiquitination enzymes is upregulated in peripheral blood monocyte during early pregnancy in dairy cattle. Reproductive Biology. 2016,16(4): 255–260.

  33.Dan Yi, Shenming Zeng, Yuming Guo. Decreased Sperm Quality in Mice Fed a Diet with Fish Oil. J. Ani. Sci. and Biotech. 2011, 2(3): 164-172.

  34.D. Yi, S. Zeng, Y. Guo A diet rich in n-3 polyunsaturated fatty acids reduced prostaglandin biosynthesis, ovulation rate, and litter size in mice. doi:10.1016/j.theriogenology. 2012.01.013

  35.Gou K.M., X.R. An, H. Guan, X. Y. Yang, J. Hou, S. E. Zhu, S. M. Zeng, J. H. Tian and Y.F.Chen. Transgenic twin lambs clonend by granulose cells. Cloning and Stem Cells. 5(1): 71-77,2003.

  36.Quan GB,TY Wu,SM Zeng,ZC Zhang,SE Zhu.A study of the cryopreservation of mouse zygotes by open pulled straw method. Cryobiology 2005,50:224.

  37.Tian XZ, Wen Q, Shi JM, Liang-Wang, Zeng SM, Tian JH, Zhou GB, Zhu SE, Liu GS. Effects of melatonin on in vitro development of mouse two-cell embryos cultured in HTF medium. Endocr Res. 2010;35(1):17-23.

  38.Shi JM, Tian XZ, Zhou GB, Wang L, Gao C, Zhu SE, Zeng SM, Tian JH, Liu GS.Melatonin exists in porcine follicular fluid and improves in vitro maturation and parthenogenetic development of porcine oocytes. J. Pineal Res. 2009, 47(4): 318-323.

  39.Zhou GB, Ma CB, Liu GS, Zhu SE, Zhang HH, Jia LL, Suo L, Shi JM, Wang YB, Tian JH, Zeng SM. Vitrification of farmed blue fox oocytes in ethylene glycol and D"TEXT-INDENT: 0cm; MARGIN-LEFT: -0.1pt;" class=MsoNormal>  40.Suo L, Wang F, Zhou GB, Shi JM, Wang YB, Zeng SM, Tian JH, Zhu SE, Liu GS. Optimal concentration of calcium and electric field levels improve tetraploid embryo production by electrofusion in mice. J Reprod Dev. 2009,55(4): 383-385.

  41. Liu GS, Zhou GB, Zhang HH, Ma CB, Shi WQ, Zhu SE, Yang ZQ, Kang J, Jia LL, Zeng SM, Tian JH, Wang F. Surgical embryo transfer resulted in birth of live offspring in farmed blue fox. Anim Reprod Sci. 2008,105(3-4):424-429.

  42.Tian JH, Wu ZH, Liu L, Cai Y, Zeng SM, Zhu SE, Liu GS, Li Y, Wu CX. Effects of oocyte activation and sperm preparation on the development of porcine embryos derived from in vitro-matured oocytes and intracytoplasmic sperm injection. Theriogenology. 2006,66(2):439-448.

  43.Liang Deng,, Hongyun Duan, Xiang Zhang, Shenming Zeng, Changxin Wu, Guocai Han, Advances in the Research and Application of Artificial Insemination to Equids in China: 1935–2012. Journal of Equine Veterinary Science. published online 21 October 2013.

  44.Jinlong Zhu, Xiangfang Zeng, Qian Peng, Shenming Zeng, Haiyi Zhao, Hexiao Shen and Shiyan Qiao. Maternal N-Carbamylglutamate Supplementation during Early Pregnancy Enhances Embryonic Survival and Development through Modulation of the Endometrial Proteome in Gilts. Journal of Nutrition. 2015, 145: 2212-2220.

近年主持的科研项目:

1、国家十一五科技支撑计划(2006BAD14B08 -05畜禽良种资源高效繁殖和生殖健康关键技术研究与产业化示范子课题羊高效排卵控制技术与推广示范20062008),经费18万。

2、国家十一五科技支撑计划(2008BAD2B09优质种用肉牛肉羊扩繁技术研究子课题高效肉羊胚胎生产技术的研究20082010),经费30万。

3、国家十一五”863计划(2008AA101003家畜卵泡高效诱导发育技术研究与应用子课题猪高效胚胎体外生产体系的研究20082010),经费15万。

4、国家动物转基因专项(2008ZX08008-005)“转基因抗病羊的培育子课题抗布氏杆菌病转基因羊的培育20082010),经费20万。

5、教育部科学技术研究重点项目(109018“MicroRNAs对猪卵泡闭锁的调控机制”(20092010),经费10万。

6、高等学校博士学科点专项科研基金Ca2+离子对猪体外成熟卵母细胞组蛋白乙酰化20102012,经费6

7、国家自然基金(31072031)“FSH抑制猪颗粒细胞中促凋亡蛋白Bim表达的分子机制20112013),经费33万。

8、国家自然基金(31172209)“IFN-τ调控牛囊胚发育的分子通路20122015, 经费60万。

9、国家转基因重大专项(2012ZX08011001-006) “转基因生物新品种培育子课题 bt基因稻米对猪生物学性状的安全评价20122015),经费98.9万。

10十二五国家863计划(2012BAI32B05子宫内膜损伤机制和治疗方法研究2012-2016),可支配经费20万,.

11、高等学校博士学科点专项科研基金(优先发展领域20130008130001猪卵泡发育中bim基因新转录因子及其调控机制研究2014-2016),经费40万。

12、国家自然基金(31470077)“FSH通过BimEL调控猪卵泡自噬的分子机制”(2015-2018),经费88万。

13、国家自然基金(31672419)“猪卵泡在闭锁过程中颗粒细胞内BimEL磷酸化修饰位点的变化规律及主要调控路径”(2017-2020),经费64万。

14、东阿阿胶集团东阿黑毛驴精液质量及输精技术提升项目方案2016-2018),经费195.2万。

15、国家重点研发计划专项(2017YFC1002003人类生育力下降机制和防护保存新策略研究 2017-2020),可支配经费81.1万。

获得的科技奖励

1哺乳动物胚胎玻璃化冷冻保存技术的研究与应用(北京市科技进步二等奖,2000,副主持)。

2牛羊胚胎生物技术研究与产业化(中国高校科学技术二等奖,2004,副主持)

3应用胚胎生物技术加快纯(良)种肉牛繁殖技术(中国高校科学技术一等奖,2002

第八完成人)。

获得发明专利

1、一种提高牛、羊胚胎移植妊娠率的方法。 专利号:200710121136.82011年授权,发明。

2、正辛醇在延缓哺乳动物卵子体外老化中的应用。专利号:201210199708.52013年授权,发明。

 

  6.教学工作及主要成绩

教学奖励

1、中国农业大学第五届青年教师基本功大赛一等奖,2005

2、中国农业大学第五届青年教师基本功大赛最佳教学演示奖,2005

3、中国农业大学动物科技学院第五届青年教师基本功大赛一等奖,2005

4、中国农业大学优秀教师,2005

5、北京市第五届青年教师基本功比赛二等奖,2007

6、参编的《家畜繁殖学》(第四版)获得全国高等农业院校优秀教材2005

7、《家畜繁殖学》课程(参讲)获得北京市精品课程,2005

8、《家畜繁殖学》课程(参讲)获得国家精品课程,2009

9、中国农业大学网络学院优秀教师,农大名师,2010

10、中国农业大学优秀教师,2011

11、《动物繁殖学》课程(主讲)获得第一批国家网络精品资源课,2016

主编专业著作

1、《鹿的养殖 疾病防治 产品加工》(中国农业出版社,1999年)

2、《奶牛胚胎移植技术》(中国农业大学出版社,2003年)

3、《猪繁殖实用技术》(中国农业出版社,2005

4、《规模化养猪猪繁殖实用技术》(中国农业出版社,2008)。

参加教材编写

1、普通高等教育十二五国家规划教材和全国高等农业院校十二五国家规划教材《家畜繁殖学》(第六版,中国农业出版社,2015年,副主编)。

2、普通高等教育十一五国家规划教材和全国高等农业院校十一五国家规划教材《家畜繁殖学》(第五版,中国农业出版社,2009年,副主编)。

3、全国高等农业院校教材和北京高等教育精品教材《家畜繁殖学》(第四版,中国农业出版社,2004年,参编)。

4、研究生教学用书《动物繁殖生物技术》(第一版,2002年;第二版,2005年,中国农业出版社,参编)。

5、全国本科生统编教材《家畜繁殖学》(第三版)(中国农业出版社,2000年,参编)。

讲授课程

  主讲本科生《家畜繁殖学》、《畜牧专业英语》、《养马学》和《马术与马文化》课程,研究《动物生殖生理》、《动物胚胎工程》、《动物繁殖技术进展与实践》和《动物大分子实验》课程、以及博士生《动物分子繁殖理论》等多门课程。




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