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胡序明
发布日期:2017-11-29浏览次数:字号:[ ]

 

  胡序明(1986-),男,重庆奉节人,中共党员,博士,讲师,硕士生导师

  通讯地址:扬州市文汇东路48号扬州大学动物科学与技术学院

  E-mailhxm@yzu.edu.cn

 

1 学习和工作简历

2004.09-2008.06

河南农业大学生物技术专业

获理学学士学位

2009.09-2014.06

扬州大学预防兽医学专业

获农学博士学位

2014.11-2017.04

扬州大学动物科学与技术学院

博士后

2017.04-

扬州大学动物科学与技术学院

讲师

2 研究方向

1)内源性反转录病毒功能及表观遗传学调控机制研究

2)长链非编码RNA功能及表观遗传学调控机制研究

 

3.科研项目

1)国家自然科学基金青年基金项目,31602032,长非编码RNA lnc-ALVE1-AS1在抗病毒天然免疫中的作用机制研究,2017/01-2019/1220万元,在研,主持

2)中国博士后科学基金第 57 批面上资助项目,2015M571828,禽内源性反转录病毒ALVE1表观遗传调控与宿主免疫关系,2015/01-2016/125万元,已结题,主持

3)扬州大学高层次人才科研启动基金,137011193,长非编码RNA lnc-ALVE1-AS1抗病毒作用机制研究,5万元,在研,主持

4)江苏省普通高校研究生科研创新计划,CXZZ12_0916RB1B感染后鸡胸腺转录组学研究,2012/01-2014/063万元,已结题,主持

5)扬州大学科技创新培育基金项目,2015CXJ052,禽内源性反转录病毒ALVE1表观遗传学调控机制研究,2015/01-2016/121万元,已结题,主持

6)国家自然科学基金重大研究计划项目,91540117,源于鸡内源性白血病病毒的反义长非编码RNA的功能及表观遗传学调控机制研究,2016/01-2018/1285万元,在研,主要参加人,排名:3/16

7)国家自然科学基金面上项目,81773013,反义RNA表观遗传沉默导致癌相关基因激活的致癌新机制研究,2018/01-2021/1255万元,在研,主要参加人,排名:2/15

8)国家自然科学基金面上项目,31472192,马立克氏病毒感染调控TLR3的分子免疫机理研究,2014/01-2016/1290万元,已结题,主要参加人

9)国家自然科学基金面上项目,31272560,马立克氏病毒感染鸡胸腺转录组学及其相关新功能基因的发现,2013/01-2016/1278万元,已结题,主要参加人

4.发表论文

1Xuming Hu, Wenqi Zhu, Shihao Chen, Yangyang Liu, Zhen Sun, Tuoyu Geng, Xiaoyan Wang, Bo Gao, Chengyi Song, Aijian Qin and Hengmi Cui, Expression patterns of endogenous avian retrovirus ALVE1 and its response to infection with exogenous avian tumour viruses, Archives of Virology, 2017,162(1): 89-101

2Yangyang Liu, Xiao Han, Junting Yuan,Tuoyu Geng, Shihao Chen,Xuming Hu, IsabelleH. Cui and Hengmi Cui,Biallelic Insertion of a Transcriptional Terminator via CRISPR/Cas9 Efficiently Silences Expression of Protein-coding and Non-coding RNA Genes, 2017, Journal of Biological Chemistry, 292(14): 5624-5633

3Shihao Chen*,  Xuming Hu*, Wenqi Zhu, ChongxinJia, Xiao Han, Junting Yuan, Zhen Sun, Zhe Yang, Tuoyu Geng, Hengmi Cui, Reactivation of development-related genes by the DNA methylation inhibitor 5-Aza-2’-deoxycytidine in chicken embryo fibroblasts, Poultry Science, 2017, 96(4):1007-1014Co-first author

4Xuming Hu, Wenqi Zhu, Shihao Chen, Yangyang Liu, Zhen Sun, Tuoyu Geng, Xiaoyan Wang, Bo Gao, Chengyi Song, Aijian Qin and Hengmi Cui, Expression of the env gene from the avian endogenous retrovirus ALVE and regulation by miR-155, Archives of Virology, 2016, 161(6): 1623-1632

5Xuming Hu, Aijian Qin, Haitao Zou, Kun Qian, Hongxia Shao and Jianqiang Ye, Activation of Toll-like receptor 3 inhibits Marek’s disease virus infection in chicken embryo fibroblast cells, Archives of Virology, 2016, 161(3): 521-528

6Xuming Hu, Aijian Qin, Haitao Zou, Kun Qian, Hongxia Shao and Jianqiang Ye, Both MicroRNA-155 and Virus-Encoded MiR-155 Ortholog Regulate TLR3 Expression,PLoS One, 2015, 10(5): e0126012

7Xuming Hu, Wencai Xu, Aijian Qin, Genghua Wu, Kun Qian, Hongxia Shao and Wenjie Jin, Transcriptional analysis of host responses to Marek's disease virus infection in chicken thymus,Intervirology, 2015, 58(2): 95-105

8Mei Mei, Jianqiang Ye, Aijian Qin, Lin wang, Xuming Hu, Kun Qian and Hongxia Shao, Identification of novel viral receptors with cell line expressing viral receptor-binding protein,Scientific Reports, 2015, 5: 7935

9Xuming Hu, Wencai Xu, Aijian Qin, Genghua Wu, Kun Qian, Hongxia Shao and Jianqiang Ye, Marek's disease virus may interfere with T cell immunity by TLR3 signals,Veterinary Research Communications, 2014, 38(2): 149-156

10Xinhong Chen, Xuming Hu, Chuan Yu, Kun Qian, Jianqiang Ye and Aijian Qin. Differential protein analysis of chicken skin infected with Marek's disease virus. Acta Virologica, 2014, 58: 43-52

11Xuming Hu, Aijian Qin, Ji Miao, Wencai Xu, Chuan Yu and Kun Qian, Transcriptional profile of Marek’s disease virus genes in chicken thymus during different phases of MDV infection,Archives of Virology, 2013, 158(8): 1787-1793

12Chuan Yu, Qiu Liu, Aijian Qin, Xuming Hu, Wencai Xu, Kun Qian, Hongxia Shao and Wenjie Jin, Expression kinetics of chicken beta-2-microglobulin and Class I MHC in vitro and in vivo during Marek's disease viral infections,Veterinary Research Communications, 2013, 37(4): 277-283

13Xuming Hu, Aijian Qin, Kun Qian, Hongxia Shao, Chuan Yu, Wencai Xu and Ji Miao, Analysis of protein expression profiles in the thymus of chickens infected with Marek's disease virus,Virol Journal, 2012, 9: 256

14Zhongjun Fan, Xuming Hu, Yongpan Zhang, Chuan Yu, Kun Qian and Aijian Qin, Proteomics of DF-1 cells infected with avian leukosis virus subgroup J,Virus Research, 2012, 167(2): 314-321

15Xuming Hu, Aijian Qin, Kun Qian, Ji Miao, Zhongjun Fan and Chuan Yu, Analysis of protein expression profiles in the bursa of Fabricius of chickens infected with Marek’s disease virus,9th International Symposium on Marek’s Disease and Avian Herpesviruses, Berlin, Germany, June 24-28, 2012

16Xuming Hu, Aijian Qin, Wencai Xu, Haitao Zou, Kun Qian, Hongxia Shao and Jianqiang Ye, Analysis of Protein Expression Profiles in Thymus of ChickensInfected with Marek’s Disease Virus,10th International Symposium on Marek’s Disease and Avian Herpesviruses, Michigan, USA, July 20-23, 2014

17Aijian Qin, Xuming Hu, Wencai Xu and Haitao Zou. Marek’s Disease Virus Infection May Associate with TLR3 Pathway,10th International Symposium on Marek’s Disease and Avian Herpesviruses, Michigan, USA, July 20-23, 2014

18)韩笑,胡序明,袁君婷,吕贝,孙振,陈世豪,耿拓宇,崔恒宓,鸡巨噬细胞HD11不同转染方法的比较分析,畜牧与兽医,2017 49 (5) : 72-76

19)袁君婷,韩笑,吕贝,胡序明,耿拓宇,崔恒宓,DNA 甲基化抑制剂 5- 氮杂 -2’-脱氧胞苷抗癌新机制初探,肿瘤,2017

20)胡序明,崔恒密,内源性反转录病毒衍生的长非编码RNA的功能,生命科学,201628(6): 695-702

21)胡序明, 朱文奇, 陈世豪,刘洋洋,孙振,耿拓宇,宋成义,高波,秦爱建,崔恒宓,禽内源性反转录病毒ALVE1 LTR转录水平分析,中国动物传染病学报,201523(5): 23(5): 27-31

22)胡序明,马立克氏病病毒感染鸡胸腺转录表达图谱及相关新功能基因的发现,中国家禽,201335(8):34

23)朱文奇, 胡序明, 陈世豪,刘洋洋,孙振,耿拓宇,宋成义,高波,王宵燕,秦爱建,崔恒宓,禽内源性反转录病毒ALVE表观遗传学分析方法建立及应用,中国动物传染病学报,201523(5): 15-20

24)朱文奇, 胡序明, 陈世豪,刘洋洋,孙振,耿拓宇,宋成义,高波,崔恒宓,miR-155体外特异性靶向鸡内源性反转录病毒ALVE1 env 转录物的研究,畜牧与兽医,201648 (5) : 711

25)范忠军,胡序明,郁川,秦爱建,王欢莉,DF-1细胞二维电泳方法的建立,河南科技大学学报,201536 (2):83-87

26)孙苹,陈倩,胡序明,叶建强,邵红霞,钱琨,秦爱建,鸡产蛋下降综合症病毒快速纯化及其多抗血清制备,中国兽药杂志,201448 (10):1-5

27)徐文财,刘秋,秦爱建,胡序明,吴庚华,孙苹,钱琨,邵红霞,金文杰,马立克氏病病毒RB1BUL14蛋白原核表达及多抗血清制备,中国动物传染病学报, 201321(3): 8-12

28)徐文财,郭卉,李旦,胡序明,吴庚华,钱琨,邵红霞,金文杰,秦爱建,荧光定量PCR检测Meq基因在马立克氏病病毒感染过程中的动力学变化,中国动物传染病学报,201321 (6): 64-67

29)徐文财,刘秋,李旦,胡序明,吴庚华,钱琨,邵红霞,金文杰,秦爱建,鸡β2-微球蛋白的基因克隆与原核表达,中国动物传染病学报,201422(1): 63-68

30)仇钰,秦爱建,钱琨,金文杰,胡序明,沈海玉,间接ELISA检测禽白血病病毒抗体方法的建立,中国家禽,201032(22):16-20

5. 奖励与荣誉

1)扬州大学优秀博士学位论文,2015

2)扬州大学优秀毕业生,2014

3)博士研究生国家奖学金,2013

4)扬州大学博士研究生学术新人奖,2013

5)朱敬文特别奖学金,2013

6)第三届全国禽病分子生物学技术青年工作者会议优秀报告奖,2013




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