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教师信息

耿拓宇

 

耿拓宇(1967-),男,江苏扬州人,博士,研究员,硕导 

通讯地址:扬州市文汇东路48 扬州大学动科学院、扬州大学表观遗传学研究所

电话:0514-87990930

E-mail tygeng@yzu.edu.cn

 

 

 

 

1. 学习与工作简历 

1985.09—1989.07 江苏农学院 学士

1989.09—1992.07 江苏农学院 硕士

1992.08—2002.08 江苏省家禽科学研究所 实习研究员、助理研究员、副研究员

2002.08—2005.07  Virginia Tech 访问学者、研究助理

2005.08—2007.05  Virginia Tech 博士

2007.06—2008.12  Duke University 博士后

2009.01—2009.12  University of Virginia 博士后

2010.01—2013.04  Medical University of South Carolina 博士后

2013.04—2017.06  扬州大学动物科学与技术学院 副研究员

2017.07—至今         扬州大学动物科学与技术学院 研究员

 

2. 研究方向

研究曾涉及动物遗传育种学和人类医学。目前的研究兴趣包括:

1)家禽遗传育种;

2)非酒精性脂肪肝形成机理的研究;

3)家禽经济性状的分子基础与关键基因的功能研究

 

3. 近期科研项目

1)国家自然科学基金面上项目“鹅肥肝形成过程中内质网应激作用的研究”(31472086), (20151~201812), 主持人

2)国家自然科学基金重大研究计划“源于鸡内源性白血病病毒的反义长非编码RNA的功能及表观遗传学调控机制研究”(91540117), (20161~201812), 排名第二

3)江苏省农业重大新品种创制项目“青脚粉壳节粮型蛋鸡配套系的培育”(PZCZ201731), (20181~202412), 排名第二

 

4. 发表论文 (SCI)

(1)         Hu X, Chen S, Jia C, Xue S, Dou C, Dai Z, Xu H, Sun Z, Geng T, Cui H. (2018) Gene expression profile and long non-coding RNA analysis, using RNA-Seq, in chicken embryonic fibroblast cells infected by avian leukosis virus. J. Arch Virol. IF=2.3.

(2)         Liu Y, Han X, Yuan J, Geng T, Chen S, Hu X, Cui IH, Cui H. (2017) Biallelic Insertion of a Transcriptional Terminator via CRISPR/Cas9 Efficiently Silences Expression of Protein-coding and Non-coding RNA Genes. J Biol Chem. 292(14):5624-5633.  IF=4.3.

(3)         Long Liu, Yanfeng Fan, Zhenhe Zhang, Yang Chan, Tuoyu Geng, Daoqing Gong, Zhuocheng Hou, Zhonghua Ning. (2017) Analysis of gene expression and regulation implicates C2H9orf152 has an important role in calcium metabolism and chicken reproduction. Animal Reproduction Science. 176:1-10. IF=1.4.

(4)         Hu X, Zhu W, Chen S, Liu Y, Sun Z, Geng T, Song C, Gao B, Wang X, Qin A, Cui H. (2017) Expression patterns of endogenous avian retrovirus ALVE1 and its response to infection with exogenous avian tumour viruses. Arch Virol. 162(1):89-101. IF=2.3.

(5)         Geng T#*, Zhao X*, Xia L, Liu L, Li F, Yang B, Wang Q, Montgomery S, Cui H, Gong D#. (2016) Supplementing dietary sugar promotes endoplasmic reticulum stress-independent insulin resistance and fatty liver in goose. Biochem Biophys Res Commun. 476(4):665-9. IF=2.4, # Corresponding author(s). * Equal contribution.

(6)         Geng T#*, Yang B*, Li F, Xia L, Wang Q, Zhao X, Gong D.# (2016) Identification of protective components that prevent the exacerbation of goose fatty liver: Characterization, expression and regulation of adiponectin receptors. Comp Biochem Physiol B Biochem Mol Biol. 194-195:32-8. IF=1.7, # Corresponding author(s). * Equal contribution.

(7)         Liu L, Zhao X, Wang Q, Sun X, Xia L, Wang Q, Yang B, Zhang Y, Montgomery S, Meng H, Geng T#, Gong D#. (2016) Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System. Sci Rep. 6:31763. IF=5.2, # Corresponding author(s).

(8)         Osman RH, Liu L, Xia L, Zhao X, Wang Q, Sun X, Zhang Y, Yang B, Zheng Y, Gong D#, Geng T#. (2016) Fads1 and 2 are promoted to meet instant need for long-chain polyunsaturated fatty acids in goose fatty liver. Mol Cell Biochem. 418(1-2):103-17. IF=2.6, # Corresponding author(s).

(9)         Zhao J, Yao J, Li F, Yang Z, Sun Z, Qu L, Wang K, Su Y, Zhang A, Montgomery SA, Geng T#, Cui H#. (2016) Identification of candidate genes for chicken early- and late-feathering. Poult Sci. 95(7):1498-503. IF=1.7, # Corresponding author(s).

(10)     Osman R. H., D. Shao, L. Liu, L. Xia, X. Sun, Y. Zheng, L. Wang, R. Zhang, Y. Zhang, J. Zhang, D. Gong#, T. Geng#. (2016). Expression of mitochondria-related genes is elevated in overfeeding-induced goose fatty liver. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology. 192:30-7. IF=1.6, # Corresponding author(s).

(11)     Hu X, Zhu W, Chen S, Liu Y, Sun Z, Geng T, Wang X, Gao B, Song C, Qin A, Cui H. (2016) Expression of the env gene from the avian endogenous retrovirus ALVE and regulation by miR-155. Arch Virol. 161(6):1623-32. IF=2.3.

(12)     Sutter A. G., A. P. Palanisamy, J. H. Lench, S. Esckilsen, T. Geng, D. N. Lewin, L. A. Cowart, K. D. Chavin. (2016) Dietary Saturated Fat Promotes Development of Hepatic Inflammation through Toll-Like Receptor 4 in Mice. Journal of Cellular Biochemistry. 117(7):1613-21. IF=3.3

(13)     Shihao Chen, Xuming Hu, Wenqi Zhu, Chongxin Jia, Xiao Han, Junting Yuan,  Zhen Sun, Zhe Yang, Tuoyu Geng, Hengmi Cui. (2016) Reactivation of development-related genes by the DNA methylation 1 inhibitor Aza-2’-deoxycytidine in chicken embryo fibroblasts. Poult Sci. 96(4): 1007–1014.  IF=1.7.

(14)     Geng T.*, A. Sutter*, M. D. Harland, B. A. Law, J. S. Ross, D. Lewin, A. Palanisamy, S. B. Russo, K. D. Chavin, L. A. Cowart. (2015) SphK1 mediates hepatic inflammation in a mouse model of nonalcoholic steatohepatitis induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes. Journal of Lipid Research. 56(12):2359-71. IF=4.4, * Equal contribution.

(15)     Geng T.# *, L. Xia*, F. Li, J. Xia, Y. Zhang, Q. Wang, B. Yang, S. Montgomery, H. Cui, D. Gong#. (2015) The role of endoplasmic reticulum stress and insulin resistance in the occurrence of goose fatty liver. Biochemical and Biophysical Research Communications. 465:83-7. IF=2.3, # Corresponding author(s). * Equal contribution.

(16)     Geng T. #, L. Xia, S. Russo, D. Kamara, L. A. Cowart. (2015) Prosteatotic genes are associated with unsaturated fat suppression of saturated fat-induced hepatic steatosis in C57BL/6 mice. Nutrition Research. 35:812-22. IF=2.5. # Corresponding author(s).

(17)     Geng T. #, X. Guan X, E. J. Smith. (2015) Screening for genes involved in antibody response to sheep red blood cells in the chicken, Gallus gallus. Poultry Science. 94: 2099-107. IF=1.7, # Corresponding author(s).

(18)     Cui L. L.,  J. F. Wang, K. Z. Xie, A. H. Li, T. Y. Geng, L. R. Sun, J. Y. Liu, M. Zhao, G. X. Zhang, G. J. Dai, J. Y. Wang.(2015) Analysis of meat flavor compounds in pedigree and two-strain Yangzhou geese. Poultry Science. 94: 2266-71. IF=1.7

(19)     Guan X., P. Silva, K. Gyenai, J. Xu, T. Geng, E. Smith.(2015) Mitochondrial DNA-Based Analyses of Relatedness Among Turkeys, Meleagris gallopavo. Biochemical Genetics. 53:29-41. IF=0.9

(20)     Geng T., W. Hu, M. H. Broadwater, J. M. Snider, J. Bielawski, S. B. Russo, J. H. Schwacke, J. Ross, L. A. Cowart. (2013) Fatty acids differentially regulate insulin resistance through endoplasm-reticulum-stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysioloigcal outcomes of obesity. Diabetologia. 56:2078-87. IF=6.9

(21)     Russo, B.S., C. F. Baicu, An Van Laer, T. Geng, H. Kasiganesan, M. R. Zile, and L.A. Cowart. (2012). Ceramide Synthase 5 mediates lipid-induced autophagy and hypotrophy in cardiomyocytes. Journal of Clinical Investigation. 122:3919-30. IF=12.8

(22)     Hu W., J. Ross, T. Geng, S.E. Brice, and L.A. Cowart. (2011) Differential regulation of dihydroceramide desaturase by palmitate vs. monounsaturated fatty acids: Implications to insulin resistance. Journal of Biological Chemistry. 286:16596-605. IF=4.8

(23)     Geng, T., P. Li, X. Yin, and Z. Yan. (2011). PGC-1α promotes nitric oxide-antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice. American Journal of Pathology. 178 (4): 1738-48. IF=4.9

(24)     Zechner C., L. Lai, J. L. Fong, T. Geng, Z. Yan, J. W. Rumsey, D. Collia, Z. Chen, D. F. Wozniak, T. C. Leone, and D. P. Kelly. (2010). Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity. Cell Metabolism. 12 (6): 633-42. IF=18.2

(25)     Geng T.*, P. Li*, M. Okutsu, X. Yin, J. Kwek, M. Zhang, and Z. Yan. (2010). PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. American Journal of Physiology-Heart and Circulatory Physiology. 298 (3):C572-579. * Equal contribution. IF=3.8

(26)     Pogozelski A. R., T. Geng, P. Li, X. Yin, V. A. Lira, M. Zhang, J. T. Chi, and Z. Yan. (2009). p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. PLoS One. 4(11). IF=4.4

(27)     Guan X., P. Silva, K. B. Gyenai, J. Xu, T. Geng, Z. Tu, D. C. Samuels, and E. J. Smith. (2009). The Mitochondrial Genome Sequence and Molecular Phylogeny of the Turkey, Meleagris gallopavo. Animal Genetics. 40:134-141. IF=2.2

(28)     Guan X., T. Geng, P. Silva, and E. J. Smith. (2007). Mitochondrial DNA Sequence and Haplotype Variation Analysis in the Chicken (Gallus gallus). Journal of Heredity. 98:723-726. IF=2.2

(29)     Lin, K.C., J. Xu, D. F. Kamara, T. Geng, K.B. Gyenai, K.M. Reed, & E. J. Smith. (2007). DNA sequence and haplotype variation in two candidate genes for dilated cardiomyopathy in the turkey, Meleagris gallopavo. Genome. 50: 463-469. IF=1.4

(30)     Kamara, D.F., T. Geng, S. Guynn, K. Hopwood, & E. J. Smith. (2007). Isolation and characterization of microsatellite markers from the budgerigar,Melopsittacus undulates. Molecular Ecology Notes. 7: 507–509.

(31)     Kamara D. F., K. B. Gyenai, T. Geng, and E. J. Smith. (2007). Microsatellite Marker-Based Genetic Analysis of Relatedness Between Commercial and Heritage Turkeys (Meleagris gallopavo). Poultry Science. 85: 46-49. IF=1.7

(32)     Lin K.C., K. B. Gyenai, R. L. Pyle, T. Geng, J. Xu, and E. J. Smith. (2006). Candidate Gene Expression Analysis of Toxin-Induced Dilated Cardiomyopathy in the Turkey (Meleagris gallopavo). Poultry Science. 85: 2216-2221. IF=1.7

(33)     Hartman S., S. A. Taleb, T. Geng, X. Guan, K. Gyenai, and E J. Smith (2006). Comparison of Plasma Uric Acid Levels in Five Varieties of the Domestic Turkey,Meleagris gallopavo. Poultry Science. 85: 1791-1794. IF=1.7

(34)     Smith E. J., T. Geng, E. C. Long, F. Pierson, D. Sponenberg, C. Larson, R. Gogal. (2005). Molecular Analysis of the Relatedness of Five Domesticated Turkey Strains. Biochemical Genetics. 43:35-47. IF=0.9

(35)     Smith E. J., D.F. Kamara, G. Pimentel, T. Geng, X. Guan, K.-C., Lin and S. Hartman. (2005). Avian Genomics: Important Resources for Understanding Vertebrate Biology. Current Genomics. 6:75-80. IF=2.3

(36)     Hartman, S., G. Touchton, J. Wynn, T. Geng, N. W. Chong, and E. J. Smith. (2005). Characterization of Expressed Sequence Tags from a Gallus gallus Pineal Gland cDNA Library. Comparative and Functional Genomics. 6:301-306. IF=2.0

5. 社会任职

1)美国生物化学与分子生物学(ASBMB)会员;

2Sigma Xi会;

3)担任Scientific Reports, Plos One, BMC Medical GeneticsWorld Journal of Gastroenterology, J Anti-Cancer Agents in Medicinal Chemistry, Journal of Cardiovascular Disease Research, Journal of Cancer Therapy的特约评审人

 

6. 教学工作

1)《表观遗传学》

2)《现代分子生物学》

地址:扬州市文汇东路48号
电话:0514-87972208
传真:0514-87350440
邮箱:dkxy@yzu.edu.cn
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