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张亚妮
发布日期:2017-09-01浏览次数:字号:[ ]

  

  张亚妮,女,陕西渭南人,副教授,硕士生导师。2002年获得西北农林科技大学学士学位,2005年获得西北农林科技大学硕士学位,2010年6月获西北农林科技大学博士学位,其中2007年10至2009年10月在加拿大圭尔夫大学生物系进行博士生联合培养。2010年7月来扬州大学工作,主要承担本科生《动物遗传学》、《渔业资源评估》、《动物遗传学实验教程》和研究生《细胞遗传学》的教学工作。主持国家自然科学基金1项,江苏省自然科学基金1项,教育部博士点基金1项, 中国博士后基金1项,中国博士后特别资助项目1项,江苏省重点研发计划(现代农业)重点项目1项, 扬州大学创新培育基金2项; 参加国家自然科学基金4项,国家转基因重大专项2项;发表论文30余篇;参与发明专利3件。

 

 一、科研项目

1. 国家自然科学基金:生殖特异性miRNA 通过Stra8 对鸡ES 细胞向雄性生殖细胞分化的调节机制(31301959 2013.01-2016.12  主持

2. 江苏省自然科学基金:以鸡内源性逆转录病毒为靶点的高效基因修饰位点的鉴定与整合效率研究(BK201613312016.07-2019.06 主持

3. 高等学校博士学科点专项科研基金Nanog基因维持鸡胚胎干细胞多能性的调节机制研究(201232501200092013.01-2015.12 主持

4. 中国博士后基金:cNanog基因在维持ESC多能性中的调节机制(2012M511326)

2013.01-2014.12 主持

5. 中国博士后特别资助 miRNA对鸡ES细胞向雄性生殖细胞分化的调节机制(2014T705502013.01-2014.12  主持

6. 扬州市科技计划项目:TGFβ信号通路在鸡胚胎干细胞向雄性生殖细胞分化的功能研究(YD20151052015.07-2017.06 主持       

7. 江苏省重点研发计划(现代农业)重点项目:优质肉用多胎绵阳新品系的选育及湖羊特色性状关键基因的挖掘(BE2015362)  2015.07- 2017.07 子项目主持

8. 国家自然科学基金:基于鸡ESCs分化为雄性生殖细胞调控关键基因和信号通路筛选诱导剂的研究(31272429) 2013.01-2016.12  参加

9. 国家自然科学基金:NLRC5受体在宿主先天免疫功能调节中的作用机制及其验证(31172199) 2011.01-2015.12 参加

10. 国家自然科学基金:PIWI蛋白介导的piRNAs在及精子发生中的功能研究(31372297 2014.01-2017.12  参加

11. 国家自然科学基金:ESCs向雄性生殖干细胞分化的特异表达新候选基因的作用机制研究(31472087 2015.01-2018.12. 参加

12. 国家自然科学基金:鸭CD8α基因甲基化及其对雏鸭肝炎作用的研究(31101704)  2011.01-2014.12  参加

13. 国家转基因重大专项:优质转基因肉羊新品种培育(2013ZX08008-0032014ZX08008-003 2014.01-2015.12 参加2013.01-2013.12 参加

 

二、荣誉称号

1. 鸡早期胚胎发育及生殖干细胞研究的理论与技术        高等学校科学研究优秀成果奖自然科学奖         教育部一等奖 排名第三 2016

2. 扬州大学教学成果奖二等奖 排名第一 2016

3.  基于思维与实践并行的动物遗传育种群研究性教学探索与实践      扬州大学教学成果奖扬州大学二等奖         排名第五 2016

4. 扬州大学“青蓝工程”优秀骨干教师   2016

5. 扬州大学“三下乡”社会实践先进工作者   2011    

6. 扬州大学校园“科技先锋”   2015    

7. 扬州大学最受欢迎的班主任   2015    

8. 扬州大学本科生优秀论文指导教师 2016         

9. 扬州大学微课比赛一等奖 2017

10 扬州大学最受欢迎的任课教师 2017        

三、发表文章

1. Zhang Y, Wang Y, Zuo Q, Li D, Zhang W, Wang F, Ji Y, Jin J, Lu Z, Wang M, Zhang C, Li B. CRISPR/Cas9 mediated chicken Stra8 gene knockout and inhibition of male germ cell differentiation. Plos one. 2017, 12(2):e0172207.

2. Yani Zhang, Yingjie Wang, Qisheng Zuo, Xiaoyan Wang, Dong Li, Beibei Tang1,2, Bichun Li. Selectionof the Inducer for the Differentiation of Chicken Embryonic Stem Cells into Male Germ Cells In Vitro. PLOS ONE, 201611(10),e0164664.

3. Yani Zhang, Qisheng Zuo, Zhiyong Liu, Dong Li, Beibei Tang, Tian-rong Xiao,Chao Lian, 4. 4. Yingjie Wang, Kai Jin, Yilin Wang, Wenhui Zhang, Bichun Li. The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. PLoS ONE, 2015, 10(11): e0140262. doi:10.1371/journal.pone.0140262.

4. Yani Zhang, Yingjie Wang, Qisheng Zuo, Dong Li, Wenhui Zhang, Chao Lian, Beibei Tang,Tianrong Xiao, Man Wang, Kehua Wang and Bichun Li. Effects of the Transforming Growth FactorBeta Signaling Pathway on the Differentiation of Chicken Embryonic Stem Cells into Male Germ Cells. CELLULAR REPROGRAMMING 2016, 186:401.

5. Yani Zhang, Dezhi Fu, Hao Chen, Zhentao Zhang, Qingqing Shi, Ahmed Kamel Elsayed, Bichun Li. Partial Antiviral Activities Detection of Chicken Mx Jointing with Neuraminidase Gene (NA) against Newcastle Disease Virus. Plos one. 2013, 8(8): e71688.

6. Yani Zhang, Haiyan Yang, Zhentao Zhang, Qingqing Shi, Dan Wang, Mengmeng Zheng, Bichun Li, Jiuzhou Song. Isolation of chicken embryonic stem cell and preparation of chicken chimeric model. Mol Biol Rep, 2013, 40(3):2149–2156.

7. Yani Zhang, Yaping Jin, Tegan A. Williams, Sally M. Burtenshaw, Amanda C. Martyn, Rui Lu. Amino acid deprivation induces CREBZF expression via an AARE in the promoter. Biochemical and Biophysical Research Communication, 2010,39(3),1352~1357.

8. Yani Zhang, Liwei Ren, Wei Li, Qi Xu, Guobin Chang, Xiaoyan Wang and Bichun Li. Cloning of neuraminidase (NA) gene and identification of its antiviral activity. African Journal of Biotechnology. 2012,11(47), 10675-10681.

9. Yani Zhang, Yongxin He, Peng Xue, Yulin Chen. Sequence variant in the KAP 1.1 gene associate with cashmere trait in two cashmere goat breeds. Africa Journal of Agriculture Research.2011,6(12):2889-2894.

10. Qisheng Zuo, Dong Li, Lei Zhang, Ahmed Kamel Elsayed, Chao Lian, Qingqing Shi, Zhentao Zhang, Rui Zhu, Yinjie WangKai Jin, Jiuzhou Song,Yani Zhang*,Bichun Li. Study on the regulatory mechanism of the lipid metabolism pathways during chicken male germ cell differentiation based on RNA-seq. Plos one.,2015, DOI:10.1371/journal.pone.0109469 (通讯作者)

11.Ahmed Kamel El-Sayed, Zhentao Zhang , Lei Zhang, Zhiyong Liu, Louise C. Abbott,Yani Zhang* , Bichun Li, Pluripotent State Induction in Mouse Embryonic Fibroblast Using mRNAs of Reprogramming Factors. Int. J. Mol. Sci. 2014, 15(12), 21840-21864.(通讯作者)

12.Dong Li, Qisheng Zuo, Chao Lian, Lei Zhang, Qingqing Shi,Zhentao Zhang, Yingjie Wang,Mahmoud F. Ahmed,Beibei Tang, Tianrong Xiao, Yani Zhang, Bichun Li. Regulatory mechanism of protein metabolic pathway during the differentiation process of chicken male germ cell. n Vitro Cellular & Developmental Biology - Animal 51.7(2015):655-661.(通讯作者)

13. Chao Lian,Qisheng Zuo,Dong Li,Lei Zhang,Mahmoud F. Ahmed,Tianrong Xiao,Beibei Tang,Yingjie Wang,Kai Jin,Yani Zhang,Bichun Li.Basing RNA-seq explored the regulatory mechanismof the carbohydrate metabolism pathways during chicken male germ cell differentiation. In Vitro Cellular & Developmental Biology - Animal, 2015, 51(7):690.(通讯作者)

14. Zhang Lei, Zhu Rui, Zuo Qisheng,Li Dong,Lian Chao,Tang Beibei,Xiao Tianrong, Zhang Yani,Li Bichun. Activity Analysis and Preliminary Inducer Screening of the Chicken DAZL Gene Promoter[J]. International journal of molecular sciences, 2015, 16(3): 6595-6605. (通讯作者)

15.Zhang Lei, Zuo Qisheng,Li Dong,Lian Chao,Ahmed Kamel Elsayed,Tang Beibei,Song Jiuzhou,Zhang Yani,Li Bichun.Study on the role of JAK/STAT signaling pathway during chicken spermatogonial stem cells generation based on RNA-Seq. Journal of integrative agriculture,2015,14(5):60354-7.(通讯作者)

16. Zhentao Zhang, Ahmed Kamel Elsayed, Qingqing Shi, Yani Zhang*, Qisheng Zuo, Dong Li, Chao Lian, Beibei Tang, Tianrong Xiao, Qi Xu, Guobin Chang, Guohong Chen, Lei Zhang, Kehua Wang, Yingjie Wang, Kai Jin, Yilin Wang, Jiuzhou Song, Hengmi Cui, and Bichun Li.Crucial genes and pathways in chicken germ stem cells differentiation. Journal of Biological Chemistry, 2015, 290(21):13605. (通讯作者)

17. Xiaoyan Wang, Yingjie Wang, Qisheng Zuo, Dong Li, Wenhui Zhang, Chao Lian, Beibei Tang, Tianrong Xiao, Man Wang, Kehua Wang, Bichun Li, Yani Zhang.The synergistic effect of 5-Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. In Vitro Cellular & Developmental Biology - Animal, 2016, 52(4):488-496.(通讯作者)

18.Yingjie Wang,Qisheng Zuo,Yulin Bi,Wenhui Zhang,Jing Jin,Liangliang Zhang,Ya-ni Zhang,Bichun Li. miR-31 Regulates Spermatogonial Stem Cells Meiosis via Targeting Stra8.[J]. Journal of Cellular Biochemistry, 2017.(通讯作者)

19. Wang Y, Bi Y, Zuo Q, Zhang W, Li D,He NN, Cheng S, Zhang YN, Li B. MAPK8 Regulates Chicken Male Germ Cell Differentiation Through JNK Signaling Pathway. J Cell Biochem. 2017 Aug 16. doi: 10.1002/jcb.26314. (通讯作者)

20. Dong Li, Shaoze Cheng, Wenhui Zhang, Man Wang, Changhua Sun,Chen Zhang, Yilin Wang, Jing Jin, Yani Zhang, Bichun LiHedgehog-Gli1 signaling regelates differentiation of chicken(Gallus gallus) embryonic stem cells to male germ cells. Animal Reproduction Science 182 (2017) 9–20. (通讯作者)

21. Dong Li, Man Wang, Shaoze Cheng, Chen Zhang, Yilin Wang, Wenhui Zhang, Ruifeng Zhao, Changhua Sun, Yani Zhang, Bichun Li. CYP1A1 based on metabolism of xenobiotics by cytochrome P450 regulates chicken male germ cell differentiation. In Vitro Cell. Dev. Biol.—Animal.2017, 53:293–303.(通讯作者)

22. Chen H,  Zuo Q,  Wang Y, Song J,  Yang H, Zhang Y,  Li B. Inducing goat pluripotent stem cells with four transcription factor mRNAs that activate endogenous promoters. BMC Biotechnol. 2017, 17(1):11. doi: 10.1186/s12896-017-0336-7.

23.Qisheng Zuo, Kai Jin, Yani Zhang, Jiuzhou Song, Bichun Li. Dynamic expression and regulatory mechanism of TGF-β signaling in chicken embryonic stem cells differentiating into spermatogonial stem cells .Bioscience ReportsJul 07, 2017,37(4), DOI: 10.1042/BSR20170179.

24. Chen Zhang, Man Wang, Nana He, Mahmoud F. Ahmed,Yilin Wang, Ruifeng Zhao, Xinjian Yu, Jing Jin, Jiuzhou Song, Qisheng Zuo, Yani Zhang, Bichun Li. Hsd3b2 associated in modulating steroid hormone synthesispathway regulates the differentiation of chicken embryonic stemcells into spermatogonial stem cells. J Cell Biochem. 2017, DOI: 10.1002/jcb.26279.

25. Zhentao Zhang, Feng Xu, Yani Zhang, Wei Li, Yanhui Yin, Caiye Zhu, Lixin Du, A. K. Elsayed, Bichun Li. Cloning and expression of MyoG gene from Hu sheep and identification of its myogenic specificity. Mol Biol Rep (2014) 41:1003–1013.

26.BC Li, W Li, H Chen, YN Zhang, ZT Zhang, XY Wang, B Gao, TC Dou, KH Wang. The Influencing Factor of In Vitro Fertilization and Embryonic Transfer in the Domestic Fowl (Gallus domesticus). Reprod Dom Anim. 2013,48(3):368-3728.

27. Hao Chen, Yanhui Yin, Yani Zhang, Min Sun, Tingfeng Chen, Caiye Zhu, Wei Li , Bichun Li, Huilin Yang. Production of transgenic mice expressing the goat H-FABP gene by intratesticular injection. Mol Biol Rep. (2013) 40:2215–2222.

28. Yurong Qin, Hao Chen, Yani Zhang, Caiye Zhu, Bo Gao, Yanhui Yin, Wei Li, Qingqing Shi, Mengmeng Zheng, Qi Xu,Jiuzhou Song, Bichun Li. Cloning of the Xuhuai goat PPARγ gene and the preparation of transgenic sheep. Biochem Genet. 2013, 51:543–553.

29. 张亚妮,王颖洁,左其生,李东,张蕾,汤贝贝,连超,毕瑜林,张文慧,李碧春. 5-AzadcTSA对鸡Nanog基因启动活性及ESC多能性维持的影响[J]. 畜牧兽医学报, 2015,46(12): 2176-2184

30. 张亚妮,任丽伟,李伟,徐琪,高波,王霄燕,李碧春.流感病毒NA基因的亚细胞定位及抗病毒活性研究.中国家禽.2012,3420: 18-22.

31. 张亚妮,杨海燕,施青青,张振韬,郑蒙蒙,王丹,李碧春.鸡胚胎干细胞的分离及其嵌合体制备条件探索.中国畜牧杂志.2012,4821:71-73.

32. 张亚妮, 陆锐. CREBZF启动子对4种氨基酸的应答效应.西北农林科技大学学报(自然科学版). 2011, 39(10), 192-198.

33. 张亚妮,张恩平,吴迪,陈玉林. 内蒙古绒山羊KAP基因与经济性状关系的研究.畜牧兽医学报,200738(5),447-451.

34. 张亚妮,张恩平,吴迪,陈玉林. KAP基因的多态性与辽宁绒山羊经济性状的关系研究.中国农业科学, 2007.40(9), 2062-2067.




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